Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
PC-3H cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetylglucosamine + N-acetyllactosamine | - |
Homo sapiens | UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta3-N-acetylglucosaminyltransferase 1 | - |
Homo sapiens |
beta3GnT1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the decrease of laminin-binding glycans and consequent increased cell migration are associated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 | down |
Homo sapiens | forced expression of beta3GnT1 in aggressive cancer cells restores the laminin-binding glycans and decreased tumor formation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | beta3GnT1 is required for laminin-binding glycan synthesis through formation of a complex with LARGE, thus regulating the function of LARGE | Homo sapiens |