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Literature summary for 2.4.1.15 extracted from
- Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme (2002), Eur. J. Biochem., 269, 6091-6100.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | - |
Mycobacterium tuberculosis |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme should be a valuable target for chemotherapeutic intervention in tuberculosis | Mycobacterium tuberculosis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4 | - |
glucose-6-phosphate | with GDPglucose as glucosyl donor | Mycobacterium tuberculosis | |
| 7 | - |
glucose-6-phosphate | with UDPglucose as glucosyl donor | Mycobacterium tuberculosis | |
| 16 | - |
GDPglucose | - |
Mycobacterium tuberculosis | |
| 18 | - |
UDPglucose | - |
Mycobacterium tuberculosis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | 10 mM, 2fold increase of activity | Mycobacterium tuberculosis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
4 * 58000, SDS-PAGE | Mycobacterium tuberculosis |
| 220000 | - |
gel filtration | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDPglucose + glucose 6-phosphate | Mycobacterium tuberculosis | - |
trehalose 6-phosphate + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-alpha-D-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | ADP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| CDP-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + CDP | - |
? | |
| GDP-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + GDP | - |
? | |
| TDP-glucose + glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + TDP | - |
? | |
| UDPglucose + glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + UDP | - |
? | |
| UDPglucose + glucose 6-phosphate | absolute specificity for glucose 6-phosphate | Mycobacterium tuberculosis | trehalose 6-phosphate + UDP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 58000, SDS-PAGE | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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