Cloned (Comment) | Organism |
---|---|
C2GnT and IGnT cDNAs are cloned and sequenced, genes are both localized on chromosome 9, band q2l, genomic structures | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | C2GnT, promyelocytic leukaemia HL-60 cells | Homo sapiens | - |
marrow cell | C2GnT is highly expressed in | Homo sapiens | - |
additional information | high expression of C2GnT in granulocyte-monocyte cell lineage | Homo sapiens | - |
PA-1 cell | IGnT, teratocarcinoma PA-1 cells | Homo sapiens | - |
T-lymphocyte | C2GnT is highly expressed in activated T lymphocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | forms branches in poly-N-acetyllactosamines | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | IGnT | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C2GnT | - |
Homo sapiens |
More | C2GnT forms the core 2 O-glycan branch, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family | Homo sapiens |