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Literature summary for 2.4.1.150 extracted from

  • Bierhuizen, M.F.A.; Maemura, K.; Kudo, S.; Fukuda, M.
    Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family (1995), Glycobiology, 5, 417-425.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
C2GnT and IGnT cDNAs are cloned and sequenced, genes are both localized on chromosome 9, band q2l, genomic structures Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell C2GnT, promyelocytic leukaemia HL-60 cells Homo sapiens
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marrow cell C2GnT is highly expressed in Homo sapiens
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additional information high expression of C2GnT in granulocyte-monocyte cell lineage Homo sapiens
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PA-1 cell IGnT, teratocarcinoma PA-1 cells Homo sapiens
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T-lymphocyte C2GnT is highly expressed in activated T lymphocytes Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family Homo sapiens ?
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?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine forms branches in poly-N-acetyllactosamines Homo sapiens ?
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UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine IGnT Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
C2GnT
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Homo sapiens
More C2GnT forms the core 2 O-glycan branch, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family Homo sapiens