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Literature summary for 2.4.1.152 extracted from

  • Niittymaki, J.; Mattila, P.; Renkonen, R.
    Cloning and expression of rat fucosyltransferase VII at sites of inflammation (2005), Apmis, 113, 613-620.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning of rat Fuc-TVII gene which is expressed as two splice variants, but only the long one shows enzymatic activity, expression of the long splice variant in COS-7 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
tunicamycin inhibits N-glycosylation of the enzyme in recombinant COS-7 cells which leads to inactivation of rFuc-TVII Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q712G6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein Tyr191 of rFuc-TVII is predicted to be O-glycosylated, three potential N-glycosylation sites at residues 86, 109, and 299, N-glycosylation is necessary for enzymatic activity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney rFuc-TVII mRNA expression undetectable in kidney but it is strongly enhanced during acute inflammatory reaction induced by kidney allograft rejection Rattus norvegicus
-
lymph node rFuc-TVII mRNA expression strongly detected in rat lymph node Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000017
-
substrate sialyl-N-acetyllactosamine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + sialyl-alpha-2,3-N-acetyllactosamine
-
Rattus norvegicus GDP + NeuNAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc
-
?

Synonyms

Synonyms Comment Organism
rat fucosyltransferase VII
-
Rattus norvegicus
rFuc-TVII
-
Rattus norvegicus
rFUT7
-
Rattus norvegicus