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Literature summary for 2.4.1.155 extracted from

  • Nakahara, S.; Saito, T.; Kondo, N.; Moriwaki, K.; Noda, K.; Ihara, S.; Takahashi, M.; Ide, Y.; Gu, J.; Inohara, H.; Katayama, T.; Tohyama, M.; Kubo, T.; Taniguchi, N.; Miyoshi, E.
    A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase (2006), FASEB J., 20, 2451-2459.
    View publication on PubMed
Search for more literature for 2.4.1.155

Application

Application Comment Organism
medicine a selective inhibitor for this GnT-V secretion, a gamma-secretase inhibitor, could provide a useful strategy for the inhibition of tumor angiogenesis and progression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens GnT-V is cleaved at the transmembrane region by gamma-secretase, and this might control tumor angiogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification Golgi-resident GnT-V is cleaved mainly in the transmembrane region by gamma-secretase, followed by its secretion Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
MIA PaCa-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GnT-V is cleaved at the transmembrane region by gamma-secretase, and this might control tumor angiogenesis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GnT-V
-
 Homo sapiens