Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.155 extracted from

  • Li, J.; Wang, X.M.; Wang, Q.; Yang, M.; Feng, X.C.; Shen, Z.H.
    Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1 (2007), Arch. Biochem. Biophys., 463, 102-109.
    View publication on PubMed
Search for more literature for 2.4.1.155

Application

Application Comment Organism
medicine the study demonstrates the effect of down-regulating GnT-V on glucose uptake and provides a new mechanistic link between GnT-V and GLUT1, since ER stress may cause apoptosis of tumor cells, selective modulation of GLUT1 may be a useful pro-apoptotic strategy for liver or other cancers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antisense GnT-V
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R Homo sapiens
-
 UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 Homo sapiens UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 ?

Synonyms

Synonyms Comment Organism
GnT-V
-
 Homo sapiens
N-acetylglucosaminyltransferase-V
-
 Homo sapiens