Cloned (Comment) | Organism |
---|---|
gene MGAT5, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GnT-V overexpression induces an aberrant E-cadherin cellular localization and alters cell morphology, GnT-V increases the stability of the cadherin/catenin complex, GnT-V leads to a reduced intercellular adhesion of gastric cells, phenotype, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | Homo sapiens | - |
UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09328 | gene MGAT5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
gastric carcinoma cell | - |
Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
Homo sapiens | UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-V | - |
Homo sapiens |
N-acetylglucosaminyltransferase V | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | GnT-V overexpression induces an aberrant E-cadherin cellular localization and alters cell morphology, fibroblastoid cells exhibit a remarkable decrease of E-cadherin membranar expression with punctual E-cadherin staining in focal areas of cell-cell contacts | Homo sapiens |
metabolism | existence of a bi-directional cross-talk between E-cadherin and two major N-glycan processing enzymes, N-acetylglucosaminyltransferase-III or -V (GnT-III or GnT-V). Molecular mechanisms underlying E-cadherin regulation in gastric cancer, overview | Homo sapiens |
physiological function | GnT-V promotes the destabilization of E-cadherin at the cell membrane leading to its mislocalization and unstable adherens-junctions with impairment of cellcell adhesion. Role pf the enzyme GnT-V in E-cadherin-mediated tumor invasion. GnT-V catalyzes the addition of ?1,6 GlcNAc branching N-glycans and is associated to increased metastasis. E-cadherin is specifically modified with bisecting GlcNAc or beta1,6 GlcNAc branched structures | Homo sapiens |