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Literature summary for 2.4.1.155 extracted from

  • Miyoshi, E.; Terao, M.; Kamada, Y.
    Physiological roles of N-acetylglucosaminyltransferase V (GnT-V) in mice (2012), BMB Rep., 45, 554-559.
    View publication on PubMed
Search for more literature for 2.4.1.155

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R Mus musculus
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 UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Mus musculus
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Mv1Lu cell
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 Mus musculus
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skin
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
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 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
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 ?

Synonyms

Synonyms Comment Organism
GnT-V
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 Mus musculus
Mgat5
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 Mus musculus
N-acetylglucosaminyltransferase V
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of GnT-V is quite low in normal liver tissue but is increased under conditions of chronic hepatitis and liver regeneration up

General Information

General Information Comment Organism
malfunction N-acetylglucosaminyltransferase-V-deficient mice are born healthy and lack beta1,6GlcNAc branches on N-glycans, but develop immunological disorders due to T-cell dysfunction at 12-20 months of age Mus musculus
physiological function enzyme overexpression of in cancer cells enhances the signaling of growth factors such as epidermal growth factor by increasing galectin-3 binding to polylactosamine structures on receptor N-glycans. Enzyme overexpression in Mv1Lu cells enhances the migration of these cells to scratch wounds. GnT-V maintains skin homeostasis by regulating the proliferation of keratinocytes through epidermal growth factor-R signaling Mus musculus