Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.155 extracted from

  • Kimura, A.; Terao, M.; Kato, A.; Hanafusa, T.; Murota, H.; Katayama, I.; Miyoshi, E.
    Upregulation of N-acetylglucosaminyltransferase-V by heparin-binding EGF-like growth factor induces keratinocyte proliferation and epidermal hyperplasia (2012), Exp. Dermatol., 21, 515-519.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
Mus musculus
-
skin
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
GnT-V
-
Mus musculus
Mgat5
-
Mus musculus
N-acetylglucosaminyltransferase-V
-
Mus musculus

General Information

General Information Comment Organism
malfunction Mgat5-deficient mouse skin is resistant to 12-O-tetradecanoyl phorbol-13-acetate-induced epidermal thickening. Cell surface epidermal growth factor receptor expression is decreased in Mgat5-deficient mouse keratinocytes Mus musculus
physiological function a high enzyme expression in keratinocytes contributes to heparin-binding epidermal growth factor-like growth factor-mediated epidermal hyperproliferation by inhibiting endocytosis of epidermal growth factor receptors bearing beta1,6 N-acetylglucosamine on their N-glycans. The enzyme plays a role in epidermal homoeostasis, particularly in hyperproliferative conditions Mus musculus