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Literature summary for 2.4.1.155 extracted from

  • Lee, J.K.; Matthews, R.T.; Lim, J.M.; Swanier, K.; Wells, L.; Pierce, J.M.
    Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V (2012), J. Biol. Chem., 287, 28526-28536.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus GnT-V can partially compensate for GnT-Vb(IX) activity in vivo ?
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 ?
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-L-Asn Mus musculus
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 UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-L-Asn
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GnT-V can partially compensate for GnT-Vb(IX) activity in vivo Mus musculus ?
-
 ?
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-L-Asn
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 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-L-Asn
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 ?

Synonyms

Synonyms Comment Organism
GnT-V
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 Mus musculus
N-acetylglucosaminyltransferase V
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 Mus musculus

General Information

General Information Comment Organism
malfunction GnT-V null brains lack N-linked, beta(1,6)-glycans but have normal levels of O-Manbeta(1,6)-branched structures Mus musculus
physiological function GnT-V is involved in synthesizing branched O-mannosyl glycans in brain Mus musculus