Literature summary for 2.4.1.155 extracted from

Lee, J.H.; Kang, J.G.; Song, K.J.; Jeon, S.K.; Oh, S.; Kim, Y.S.; Ko, J.H.
N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells (2013), Biochem. Biophys. Res. Commun., 431, 658-663.

Search for more literature for 2.4.1.155

Cloned(Commentary)

Cloned (Comment)	Organism
gene MGAT5, quantitative real-time PCR enzyme expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme downregulation in cancer cells by specific shRNA expression	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q09328	gene MGAT5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Colo-205 cell	-	Homo sapiens	-
colon	-	Homo sapiens	-
colon cancer cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MKN-45 cell	-	Homo sapiens	-
additional information	quantitative enzyme expression analysis in cancer cells, overview	Homo sapiens	-
WiDr cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GnT-V	-	Homo sapiens
N-acetylglucosaminyltransferase V	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme that catalyzes the formation of a beta1,6-N-acetylglucosamine side chain to a core mannosyl residue in N-linked glycoproteins. Besides its direct function of producing aberrant glycoproteins, it promotes cancer progression by its involvement in the stimulation of oncoproteins. Enzyme GnT-V guides the transcriptional activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) in cancer cells. The activated MT1-MMP expression has dual effects on cancer progression. It not only promotes proteolytic activity for cancer cells per se, but also leads to the activation of MMP-2. Consequently, the activation of the two MMPs triggered by GnT-V intensifies the invasive potential. Cancer invasion is stimulated by GnT-V-induced activation of both MT1-MMP and MMP-2	Homo sapiens

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Release 2023.1 (January 2023)