Cloned (Comment) | Organism |
---|---|
gene BmChsA, semiquantitative RT-PCR expression analysis, expression pattern | Bombyx mori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nikkomycin Z | a chitin synthase inhibitor that downregulates the expression of BmChsA and decreases the amount of epidermis chitin during the molting process | Bombyx mori |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bombyx mori | H6WW31 | gene BmChsA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | gene BmChsA is an epidermis-specific expressed gene during the molting stage, BmChsA gene in the epidermis of the head | Bombyx mori | - |
head | BmChsA gene in the epidermis of the head | Bombyx mori | - |
integument | BmChsA is an integument-specific expressed gene | Bombyx mori | - |
larva | gene BmChsA is an epidermis-specific expressed gene during the molting stage | Bombyx mori | - |
additional information | semiquantitative RT-PCR expression analysis and expression pattern, overview | Bombyx mori | - |
Synonyms | Comment | Organism |
---|---|---|
chitin synthase A | - |
Bombyx mori |
Organism | Comment | Expression |
---|---|---|
Bombyx mori | nikkomycin Z, a chitin synthase inhibitor, downregulates the expression of BmChsA and decreases the amount of epidermis chitin during the molting process | down |
Bombyx mori | exogenous hormones, 20-hydroxyecdysone and methoprene, significantly upregulate the expression of gene BmChsA at low levels of endogenous molting hormone and high levels of endogenous juvenile hormone immediately after molting. With low levels of endogenous hormones during the mulberry intake process, BmChsA is rarely upregulated by exogenous hormones. With high levels of endogenous molting hormone and low levels of endogenous juvenile hormone during the molting stage, upregulation of gene BmChsA by exogenous hormones is not detected | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of BmChsA gene in third instar larvae increases the number of non-molting and abnormal molting larvae | Bombyx mori |
physiological function | chitin synthase is the key regulatory enzyme for chitin synthesis and excretion in insects, as well as a specific target of insecticides. Chitin synthase A gene BmChsA is an epidermis-specific expressed gene during the molting stage. Expression of gene BmChsA is regulated by endocrine hormones, which directly affect the chitin synthesis-dependent epidermal regeneration and molting process. BmChsA gene expression is strongly regulated by 20-hydroxyecdysone | Bombyx mori |