Cloned (Comment) | Organism |
---|---|
transgenic mice overexpress the enzyme in the skeletal muscle of mdx animals | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Mus musculus | overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals | UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals | Mus musculus | UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |