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Literature summary for 2.4.1.17 extracted from
- The enzyme-catalyzed formation of bilirubin diglucurionide by a solubilized preparation from cat liver microsomes (1974), Biochim. Biophys. Acta, 338, 170-182.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.36 | - |
UDPglucuronate | 0.017 mM bilirubin monoglucuronide added, at pH 6.5 | Felis catus |  |
| 0.44 | - |
UDPglucuronate | 0.016 mM bilirubin monoglucuronide added, at pH 8.1 | Felis catus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Felis catus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Felis catus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Felis catus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + UDPglucuronate | - |
Felis catus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
conversion of bilirubin monoglucuronide to bilirubin diglucuronide, second optimum at pH 8.1 | Felis catus |
| 8 | 8.8 | glucuronidation of bilirubin | Felis catus |
| 8.1 | - |
conversion of bilirubin monoglucuronide to bilirubin diglucuronide, second optimum at pH 6.5 | Felis catus |
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