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Literature summary for 2.4.1.17 extracted from
- Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides (1973), Biochem. J., 131, 139-147.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Phenobarbital | - |
Rattus norvegicus |  |
| Phenobarbital | stimulation of the enzyme in cultured 11-day embryo liver | Gallus gallus | |
| UDP-N-acetylglucosamine | activation | Gallus gallus | |
| UDP-N-acetylglucosamine | activation | Mus musculus | |
| UDP-N-acetylglucosamine | activation | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | effect of UDP-N-acetylglucosamine as activator | Gallus gallus | |
| additional information | - |
additional information | effect of UDP-N-acetylglucosamine as activator | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Gallus gallus | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | no effect | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus | - |
Gunn strain | - |
| Rattus norvegicus | - |
distribution in Wistar and Gunn strain | - |
| Rattus norvegicus Gunn | - |
Gunn strain | - |
| Rattus norvegicus Gunn | - |
distribution in Wistar and Gunn strain | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Gallus gallus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| stomach | - |
Mus musculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, microsomal preparation: increase of activity towards 4-nitrophenol, maximum of activation at 3 days storage | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrothiophenol + UDP-glucuronate | - |
Gallus gallus | 4-nitrothiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| 4-nitrothiophenol + UDP-glucuronate | - |
Mus musculus | 4-nitrothiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| 4-nitrothiophenol + UDP-glucuronate | - |
Rattus norvegicus | 4-nitrothiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| 4-nitrothiophenol + UDP-glucuronate | - |
Rattus norvegicus Gunn | 4-nitrothiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| 4-nitrothiophenol + UDP-glucuronate | - |
Rattus norvegicus Wistar | 4-nitrothiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| thiophenol + UDPglucuronate | - |
Rattus norvegicus | thiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| thiophenol + UDPglucuronate | - |
Rattus norvegicus Gunn | thiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
| thiophenol + UDPglucuronate | - |
Rattus norvegicus Wistar | thiophenyl thio-beta-D-glucuronide + UDP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 7.8 | 4-thionitrophenol, thiophenol and 4-nitrophenol as substrates | Rattus norvegicus |
| 7.4 | - |
4-nitrothiophenol | Rattus norvegicus |
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