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Literature summary for 2.4.1.17 extracted from

  • Jansen, P.L.M.; Mulder, G.J.; Burchell, B.; Bock, K.W.
    New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease" (1992), Hepatology, 15, 532-544.
    View publication on PubMed
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
3-methylcholanthrene induces glucuronidation of planar phenols Rattus norvegicus
Phenobarbital
-
 Homo sapiens
Phenobarbital induces bilirubin glucuronidation Rattus norvegicus
UDP-N-acetylglucosamine presumed physiological activator Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Rattus norvegicus
several UGT cloned. Persistently increased expression of phenol-UGT in rat hepatocyte nodules, hepatoma H4IIE cells and various rat liver epithelial cell lines. Expressed in human lung carcinoma A549 cells and human breast cancer MCF7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2,2-triphenyl-UDP selective inhibitor Rattus norvegicus
7,7,7-Triphenylheptanoic acid competitive to bilirubin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Rattus norvegicus 5789
-
endoplasmic reticulum membrane sequencing data indicate that the enzymes are anchored in the membrane by a carboxy-terminal hydrophobic domain, with a bulk of the polypeptide chain located within the cisternal lumen of the endoplasmic reticulum Homo sapiens 5789
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 overview
-
Rattus norvegicus
-
 overview
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information Gunn rat strain, inducible phenol-UGT synthesized in the truncated form is not the result of a posttranslational modification Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
two isozymes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + UDPglucuronate
-
 Homo sapiens bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate expressed after birth Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
additional information substrate specificity determinates by amino acid sequences in the variable amino-terminal half of the enzyme molecule Rattus norvegicus ?
-
 ?
planar phenols + UDPglucuronate expressed before birth Rattus norvegicus UDP + phenylglucuronides
-
 ?