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Literature summary for 2.4.1.17 extracted from

  • Bruck, M.; Li, Q.; Lamb, J.G.; Tukey, R.H.
    Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4 (1997), Arch. Biochem. Biophys., 344, 357-364.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
UGT1A71, UGT1a6 and UGT1A4 expressed in COS-1 cells Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.037
-
 imipramine UGT1A41 Oryctolagus cuniculus
0.14
-
 imipramine UGT1A71 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 rabbit
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activities of 14 substrates for UGTA1A7 and UGTA1A6 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxybiphenyl + UDPglucuronate conjugated by UGT1A71 but not by UGT1A61 Oryctolagus cuniculus UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
 ?
4-hydroxyestrone + UDP-glucuronate conjugated by UGT1A71 but not by UGT1A61 Oryctolagus cuniculus UDP + 4-hydroxyestrone 4-O-glucuronide
-
 ?
4-n-octylgallate + UDPglucuronate highly specific for UGT1A71 Oryctolagus cuniculus UDP + 4-n-octylgallate 3-O-glucuronide
-
 ?
4-nitrophenol + UDP-glucuronate
-
 Oryctolagus cuniculus 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
bilirubin + UDPglucuronate UGT1A61: no activity Oryctolagus cuniculus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
estradiol-17beta + UDPglucuronate UGT1A61 no activity Oryctolagus cuniculus estradiol-17beta-3-monoglucuronide + UDP
-
 ?
estrone + UDPglucuronate UGT1A61 inactive Oryctolagus cuniculus UDP + estrone 3-O-glucuronide
-
 ?
imipramine + UDPglucuronate conjugated by UGT1A7 but not by UGT1A4 Oryctolagus cuniculus UDP + ?
-
 ?
additional information tertiary amines give quaternary ammonium glucuronides when conjugated by UGT1A7 but not by UGT1A4 Oryctolagus cuniculus ?
-
 ?