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Literature summary for 2.4.1.17 extracted from

  • Radominska-Pandya, A.; Czernik, P.J.; Little, J.M.; Battaglia, E.; Mackenzie, P.I.
    Structural and functional studies of UDP-Glucuronosyltransferases (1999), Drug Metab. Rev., 31, 817-899.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
different isozymes expressed in COS-7 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Diethyldithiocarbamic acid sodium salt irreversible inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Rattus norvegicus
additional information
-
 additional information Km values for 31 xenobiotics reported Homo sapiens
0.0066
-
 androsterone apparent Km for UGT2B7 Homo sapiens
0.01
-
 4-hydroxyestradiol apparent Km for UGT2B7 Homo sapiens
0.01
-
 androsterone apparent Km for UGT2B7(H) Homo sapiens
0.011
-
 hyodeoxycholic acid apparent Km for UGT2B7(H) Homo sapiens
0.014
-
 4-hydroxyestrone apparent Km for UGT2B7 Homo sapiens
0.016
-
 5alpha-androstane-3alpha,17beta diol apparent Km for UGT1A4 Homo sapiens
0.021
-
 2-hydroxyestrone apparent Km for UGT1A3 Homo sapiens
0.024
-
 bilirubin apparent Km for UGT1A1 Homo sapiens
0.024
-
 2-hydroxyestrone apparent Km for UGT1A1 Homo sapiens
0.024
-
 2-hydroxyestradiol apparent Km for UGT1A3 Homo sapiens
0.025
-
 2-hydroxyestradiol apparent Km for UGT1A1 Homo sapiens
0.27
-
 hyodeoxycholic acid apparent Km for UGT2B4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-
endoplasmic reticulum
-
 Homo sapiens 5783
-
endoplasmic reticulum membrane
-
 Rattus norvegicus 5789
-
endoplasmic reticulum membrane transmembrane protein with a lumenal domain consisting of about 95% of the polypeptide chain and a cytoplasmic domain of only 20 or so residues Homo sapiens 5789
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Homo sapiens
-
-
nuclear membrane
-
 Homo sapiens 31965
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus
-
 ?
-
 ?
additional information Homo sapiens wide variety of endogenous steroidal hormones, bile acids, retinoids and tyroid hormones glucuronidated by isozymes of UGT1A family ?
-
 ?
additional information Homo sapiens steroid hormones, bile acids, all trans retinoic acids and fatty acids glucuronidated by isozymes of UGTB2 family ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224 overview
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose
-
 Homo sapiens
-
adrenal gland
-
 Rattus norvegicus
-
breast
-
 Homo sapiens
-
gall bladder
-
 Homo sapiens
-
gastrointestinal tract
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-
lung
-
 Rattus norvegicus
-
lung
-
 Homo sapiens
-
mammary gland
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
skin
-
 Rattus norvegicus
-
skin
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyestradiol + UDPglucuronate
-
 Homo sapiens UDP + 2-hydroxyestradiol O-glucuronide
-
 ?
2-hydroxyestrone + UDPglucuronate
-
 Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP
-
 ?
4-hydroxyestradiol + UDPglucuronate
-
 Homo sapiens UDP + 4-hydroxyestradiol O-glucuronide
-
 ?
4-hydroxyestrone + UDP-glucuronate
-
 Homo sapiens UDP + 4-hydroxyestrone 4-O-glucuronide
-
 ?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
-
 Homo sapiens UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
-
 ?
androsterone + UDPglucuronate
-
 Rattus norvegicus UDP + androsterone O-glucuronide
-
 ?
androsterone + UDPglucuronate
-
 Homo sapiens UDP + androsterone O-glucuronide
-
 ?
bilirubin + UDPglucuronate
-
 Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate
-
 Homo sapiens bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
additional information
-
 Rattus norvegicus ?
-
 ?
additional information wide variety of endogenous steroidal hormones, bile acids, retinoids and tyroid hormones glucuronidated by isozymes of UGT1A family Homo sapiens ?
-
 ?
additional information steroid hormones, bile acids, all trans retinoic acids and fatty acids glucuronidated by isozymes of UGTB2 family Homo sapiens ?
-
 ?
morphine + UDP-glucuronate
-
 Rattus norvegicus UDP + morphine 3,6-diglucuronide
-
 ?
morphine + UDP-glucuronate
-
 Homo sapiens UDP + morphine 3,6-diglucuronide
-
 ?
scopoletin + UDPglucuronate
-
 Homo sapiens UDP + scopoletin O-glucuronide
-
 ?
testosterone + UDPglucuronate
-
 Rattus norvegicus UDP + testosterone O-glucuronide
-
 ?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
-
 Homo sapiens UDP + ?
-
 ?

Subunits

Subunits Comment Organism
? apparent homodimers and heterodimers of UGT2B1 and UGT1A6 Homo sapiens
? all values determined by SDS-PAGE Rattus norvegicus
? all values determined by SDS-PAGE Homo sapiens