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Literature summary for 2.4.1.17 extracted from
- Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6 (2003), Drug Metab. Dispos., 31, 133-139.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| 4.9 | - |
serotonin | lung UGT1A6, pH 7.5, 37°C | Homo sapiens |  |
| 5.2 | 8.8 | serotonin | liver UGT1A6, pH 7.5, 37°C | Homo sapiens | |
| 6.5 | - |
serotonin | kidney UGT1A6, pH 7.5, 37°C | Homo sapiens | |
| 12.4 | - |
serotonin | intestine UGT1A6, pH 7.5, 37°C | Homo sapiens | |
| 55.9 | - |
serotonin | recombinant UGT1A6 from lymphoblasts or insect cells, pH 7.5, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19224 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | tissue-specific serotonin glucuronidation activity | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity of isozyme UGT1A6 in microsomes of different tissues | Homo sapiens |
| 0.00077 | 0.033 | liver UGT1A6 of different individuals, microsomes | Homo sapiens |
| 0.0158 | - |
recombinant UGT1A6 from lymphoblasts or insect cells, microsomes | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + 4-nitrophenol | recombinant isozyme UGT1A6 from lymphoblasts or insect cells | Homo sapiens | UDP + 4-nitrophenyl beta-D-glucuronide | - |
? | |
| UDP-glucuronate + serotonin | in vitro substrate, isozyme UGT1A6 | Homo sapiens | UDP + serotonin beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase 1A6 | - |
Homo sapiens |
| UGT1A6 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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