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Literature summary for 2.4.1.17 extracted from

  • Xiong, Y.; Bernardi, D.; Bratton, S.; Ward, M.D.; Battaglia, E.; Finel, M.; Drake, R.R.; Radominska-Pandya, A.
    Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis (2006), Biochemistry, 45, 2322-2332.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-azido-2-hydroxybenzoic acid inhibition of UGT1A10 catalyzed glucuronidation of 4-nitrophenol Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0496
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens
0.0522
-
4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
0.0766
-
4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
0.0924
-
4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
0.1226
-
4-Methylumbelliferone 37°C Homo sapiens
0.1508
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens
0.2376
-
4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
0.3359
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens
0.5191
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens
0.803
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens
1.034
-
4-nitrophenol 37°C, pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656
-
-
Homo sapiens P19224
-
-
Homo sapiens P22309
-
-
Homo sapiens Q9HAW7
-
-
Homo sapiens Q9HAW8
-
-
Homo sapiens Q9HAW9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-azido-4-chlorobenzoic acid + UDP-glucuronate
-
Homo sapiens ?
-
?
3-azidobenzoic acid + UDP-glucuronate
-
Homo sapiens ?
-
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
-
Homo sapiens ?
-
?
4-azidobenzoic acid + UDP-glucuronate
-
Homo sapiens ?
-
?
4-methylumbelliferone + UDP-glucuronate
-
Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
?
4-methylumbelliferone + UDP-glucuronate Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-methylumbelliferone Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
?
4-nitrophenol + UDP-glucuronate
-
Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
?
4-nitrophenol + UDP-glucuronate Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-nitrophenol Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 1A1
-
Homo sapiens
UDP-glucuronosyltransferase 1A10
-
Homo sapiens
UDP-glucuronosyltransferase 1A6
-
Homo sapiens
UDP-glucuronosyltransferase 1A7
-
Homo sapiens
UDP-glucuronosyltransferase 1A8
-
Homo sapiens
UDP-glucuronosyltransferase 1A9
-
Homo sapiens
UGT-1J
-
Homo sapiens
UGT1-10
-
Homo sapiens
UGT1.10
-
Homo sapiens
UGT1A1
-
Homo sapiens
UGT1A6
-
Homo sapiens
UGT1A7
-
Homo sapiens
UGT1A8
-
Homo sapiens
UGT1A9
-
Homo sapiens
UGT1J
-
Homo sapiens