Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluconazole | 2.5 mM, 0.075 mM naproxen, 72% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.072 | - |
naproxen | 37°C, pH 7.4 | Homo sapiens | |
0.855 | - |
naproxen | 37°C, pH 7.4 | Homo sapiens | |
3.133 | - |
desmethylnaproxen | 37°C, pH 7.4 | Homo sapiens | |
3.384 | - |
desmethylnaproxen | 37°C, pH 7.4 | Homo sapiens | |
4.375 | - |
naproxen | 37°C, pH 7.4 | Homo sapiens | |
7.724 | - |
desmethylnaproxen | 37°C, pH 7.4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDPglucuronate + naproxen | Homo sapiens | UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | - |
- |
Homo sapiens | P16662 | - |
- |
Homo sapiens | P19224 | - |
- |
Homo sapiens | P22309 | - |
- |
Homo sapiens | P35503 | - |
- |
Homo sapiens | Q9HAW7 | - |
- |
Homo sapiens | Q9HAW9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + desmethylnaproxen | UGT 1A3 forms only the acyl glucuronide | Homo sapiens | ? | - |
? | |
UDP-glucuronate + desmethylnaproxen | UGT 1A6 forms only the acyl glucuronide | Homo sapiens | ? | - |
? | |
UDP-glucuronate + desmethylnaproxen | UGT1A1 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen | Homo sapiens | ? | - |
? | |
UDP-glucuronate + desmethylnaproxen | UGT1A7 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen UGT 1A6 forms only the acyl glucuronide | Homo sapiens | ? | - |
? | |
UDP-glucuronate + desmethylnaproxen | UGT1A9 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen UGT 1A6 forms only the acyl glucuronide | Homo sapiens | ? | - |
? | |
UDP-glucuronate + desmethylnaproxen | UGT2B7 forms only the acyl glucuronide | Homo sapiens | ? | - |
? | |
UDP-glucuronate + naproxen | - |
Homo sapiens | ? | - |
? | |
UDP-glucuronate + naproxen | UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug | Homo sapiens | ? | - |
? | |
UDPglucuronate + naproxen | UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DP-glucuronosyltransferase 1A3 | - |
Homo sapiens |
UDPGT | - |
Homo sapiens |
UGT1-03 | - |
Homo sapiens |
UGT1.3 | - |
Homo sapiens |
UGT1A1 | - |
Homo sapiens |
UGT1A3 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
UGT1A7 | - |
Homo sapiens |
UGT1A8 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |