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Literature summary for 2.4.1.17 extracted from

  • Kaji, H.; Kume, T.
    Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A) (2005), Drug Metab. Pharmacokinet., 20, 212-218.
    View publication on PubMed
Search for more literature for 2.4.1.17

Inhibitors

Inhibitors Comment Organism Structure
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens
bilirubin 0.1 mM, 95.7% inhibition. 0.003 mM, 64.7% inhibition; 0.1 mM, very weak inhibition; very weak inhibition Homo sapiens
diclofenac 0.01 mM, 40.6% inhibition. 0.03 mM, 67% inhibition; very weak inhibition; weak; weak Homo sapiens
genistein 0.003 mM, 25.4% inhibition. 0.03 mM, 79.5% inhibition; 0.003 mM, 38.8% inhibition. 0.03 mM, 97.6% inhibition; weak; weak Homo sapiens
propofol 0.03 mM, weak inhibition; 0.1 mM, weak; weak inhibition at 0.03 mM, moderate inhibition at 0.1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0119
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens
0.0456
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens
0.138
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens
0.293
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine ?
-
 ?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans ?
-
 ?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656 recombinant
-
Homo sapiens P16662 recombinant
-
Homo sapiens P22309 recombinant
-
Homo sapiens P35503 recombinant
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine Homo sapiens ?
-
 ?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans Homo sapiens ?
-
 ?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
UGT1A1
-
 Homo sapiens
UGT1A3
-
 Homo sapiens
UGT1A9
-
 Homo sapiens
UGT2B7
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.56
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens