Any feedback?
Literature summary for 2.4.1.17 extracted from
- Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide (2005), Life Sci., 77, 683-692.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| silibinin-glucuronide | cmpetitive; competitive | Rattus norvegicus |  |
| silymarin | competitive | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q64550 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + p-nitrophenol | - |
Rattus norvegicus | UDP + 4-nitrophenyl-alpha-D-glucuronide | - |
? | |
| UDPglucuronate + bilirubin | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bilirubin-specific UDPGT isozyme 1 | - |
Rattus norvegicus |
| HUG-BR1 | - |
Rattus norvegicus |
| phenol-metabolizing UDP-glucuronosyltransferase | - |
Rattus norvegicus |
| UDP-glucuronosyltransferase 1A1 | - |
Rattus norvegicus |
| UDP-glucuronosyltransferase 1A6 | - |
Rattus norvegicus |
| UDPGT | - |
Rattus norvegicus |
| UGT-1A | - |
Rattus norvegicus |
| UGT-1F | - |
Rattus norvegicus |
| UGT1-01 | - |
Rattus norvegicus |
| UGT1-06 | - |
Rattus norvegicus |
| UGT1.1 | - |
Rattus norvegicus |
| UGT1.6 | - |
Rattus norvegicus |
| UGT1A | - |
Rattus norvegicus |
| UGT1A1 | - |
Rattus norvegicus |
| UGT1A6 | - |
Rattus norvegicus |
| UGT1F | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki-value for silibinin-glucuronide at 37°C, pH 7.8 is 0.016 mg/ml | Rattus norvegicus | |
| additional information | - |
additional information | Ki-value for silibinin-glucuronide at 37°C, pH 8.0 is 0.014 mg/m. Ki-value for silymarin at 37°C, pH 8.0 is 0.051 mg/ml | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
