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Literature summary for 2.4.1.17 extracted from
- Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats (2005), Pharm. Res., 22, 2007-2015.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P08541 | - |
- |
| Rattus norvegicus | P09875 | - |
- |
| Rattus norvegicus | P20720 | - |
- |
| Rattus norvegicus | P36511 | - |
- |
| Rattus norvegicus | Q62789 | - |
- |
| Rattus norvegicus | Q64550 | - |
- |
| Rattus norvegicus | Q64634 | - |
- |
| Rattus norvegicus | Q64637 | - |
- |
| Rattus norvegicus | Q64638 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | both the activity and mRNA expression of UG2T2B12 are decreased after initiation of hepatic regeneration and recovered completely by day 6 | Rattus norvegicus | - |
| liver | both the activity and mRNA expression of UGT2B2 are decreased after initiation of hepatic regeneration and recovered completely by day 6 | Rattus norvegicus | - |
| liver | expression of UGT1A5 mRNA is not altered by partial hepatectomy | Rattus norvegicus | - |
| liver | expression of UGT1A8 mRNA is not altered by partial hepatectomy | Rattus norvegicus | - |
| liver | expression of UGT2B8 mRNA is down-regulated during hepatic regeneration | Rattus norvegicus | - |
| liver | mRNA expression of UGT1A2 is increased during hepatic regeneration | Rattus norvegicus | - |
| liver | mRNA expression of UGT1A3 is increased during hepatic regeneration | Rattus norvegicus | - |
| liver | the activity of UGT1A1 is decreased 24 h and 6 days after partial hepatectomy and recovered by day 14. The mRNA expression of UGT1A1 is also decreased 24 h and 6 days after initiation of regeneration and returns to normal level by day 14 | Rattus norvegicus | - |
| liver | the activity of UGT2B1 is decreased 24 h after partial hepatectomy. The mRNA expression of UGT2B1 is also decreased 24 h after regeneration and returns back to normal level by day 6 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (-)-borneol + UDP-glucuronate | - |
Rattus norvegicus | UDP + (-)-borneol-O-alpha-D-glucuronide | - |
? |  |
| androsterone + UDP-glucuronate | - |
Rattus norvegicus | ? | - |
? | |
| estradiol + UDP-glucuronate | - |
Rattus norvegicus | ? | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UGT1A1 | - |
Rattus norvegicus |
| UGT1A2 | - |
Rattus norvegicus |
| UGT1A3 | - |
Rattus norvegicus |
| UGT1A5 | - |
Rattus norvegicus |
| UGT1A8 | - |
Rattus norvegicus |
| UGT2B1 | - |
Rattus norvegicus |
| UGT2B12 | - |
Rattus norvegicus |
| UGT2B2 | - |
Rattus norvegicus |
| UGT2B8 | - |
Rattus norvegicus |
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