Cloned (Comment) | Organism |
---|---|
expressed in HEK293 cells | Papio anubis |
UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview | Papio anubis |
Protein Variants | Comment | Organism |
---|---|---|
A235V | C704T, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
A26V | C77T, naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
A432G | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
A483G | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
A498T | G1492A, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
A58V | C173T, naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
A7G | C20G, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
A966C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
A966C | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
C117T | naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
C1494T | naturally occuring polymorphism of isozyme UGT1A1 | Papio anubis |
C1497T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
C1545T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
C489T | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
C639T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
C663T | naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
C702T | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
C966A | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
G12C | naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
G1368T | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
G174A | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
G399A | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
G720A | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
G804A | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
H225D | C673G, naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
K30N | G90C, naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
M214V | A640G, naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
N276S | A827G, naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
P219T | C655A, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
R516W | C1546T, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
R51S | G153T, naturally occuring polymorphism of isozyme UGT1A7 | Papio anubis |
R91H | G272A, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
T1368G | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
T1497C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
T1545C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
T646C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
T702C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
T750C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
T750C | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
V24G | T71G, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
V56F | G166T, naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
W512R | C1534T, naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
Y216H | T648C, naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Papio anubis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | ? | - |
? | |
additional information | Papio anubis | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | ? | - |
? | |
UDP-glucuronic acid + bilirubin | Papio anubis | - |
UDP + bilirubin-glucuronoside | - |
? | |
UDP-glucuronic acid + bilirubin | Homo sapiens | UGT1A1 | UDP + bilirubin-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes UGT1 and UGT2 | - |
Papio anubis | Q20CK6 | - |
- |
Papio anubis | Q20CK6 | isozyme UGT1A10B; gene UGT1A10B | - |
Papio anubis | Q20CK7 | - |
- |
Papio anubis | Q20CK7 | isozyme UGT1A8; gene UGT1A8 | - |
Papio anubis | Q20CK8 | - |
- |
Papio anubis | Q20CK8 | isozyme UGT1A10A; gene UGT1A10A | - |
Papio anubis | Q20CK9 | - |
- |
Papio anubis | Q20CK9 | isozyme UGT1A9; gene UGT1A9 | - |
Papio anubis | Q20CL0 | - |
- |
Papio anubis | Q20CL0 | isozyme UGT1A7; gene UGT1A7 | - |
Papio anubis | Q20CL1 | - |
- |
Papio anubis | Q20CL1 | isozyme UGT1A6; gene UGT1A6 | - |
Papio anubis | Q20CL2 | - |
- |
Papio anubis | Q20CL2 | isozyme UGT1A5B; gene UGT1A5B | - |
Papio anubis | Q20CL3 | - |
- |
Papio anubis | Q20CL3 | isozyme UGT1A5A; gene UGT1A5A | - |
Papio anubis | Q20CL4 | - |
- |
Papio anubis | Q20CL4 | isozyme UGT1A4; gene UGT1A4 | - |
Papio anubis | Q20CL5 | - |
- |
Papio anubis | Q20CL5 | isozyme UGT1A2A; gene UGT1A2A | - |
Papio anubis | Q20CL6 | - |
- |
Papio anubis | Q20CL6 | isozyme UGT1A1; gene UGT1A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrointestinal tract | isozymes UGT1 and UGT2 | Homo sapiens | - |
ileum | - |
Papio anubis | - |
ileum | isozyme UGT1A7 | Papio anubis | - |
ileum | isozyme UGT1A8 | Papio anubis | - |
ileum | isozyme UGT1A10A | Papio anubis | - |
ileum | isozyme UGT1A10B | Papio anubis | - |
ileum | isozyme UGT1A4 | Papio anubis | - |
ileum | isozyme UGT1A5A | Papio anubis | - |
ileum | isozyme UGT1A5B | Papio anubis | - |
kidney | isozymes UGT1 and UGT2 | Homo sapiens | - |
liver | - |
Papio anubis | - |
liver | isozyme UGT1A1 | Papio anubis | - |
liver | isozyme UGT1A9 | Papio anubis | - |
liver | isozyme UGT1A2A | Papio anubis | - |
liver | isozyme UGT1A6 | Papio anubis | - |
liver | isozymes UGT1 and UGT2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaminophen + UDP-glucuronate | - |
Papio anubis | ? | - |
? | |
additional information | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | Homo sapiens | ? | - |
? | |
additional information | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | Papio anubis | ? | - |
? | |
serotonin + UDP-glucuronate | - |
Papio anubis | UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide | - |
? | |
UDP-glucuronate + 1-naphthol | - |
Papio anubis | UDP + beta-D-glucuronosyl-(1-naphthol) | - |
? | |
UDP-glucuronate + 4-methylumbelliferone | - |
Papio anubis | UDP + beta-D-glucuronosyl-(4-methylumbelliferone) | - |
? | |
UDP-glucuronate + 4-nitrophenol | - |
Papio anubis | UDP + 4-nitrophenyl beta-D-glucuronide | - |
? | |
UDP-glucuronate + buprenorphine | - |
Papio anubis | UDP + buprenorphine glucuronide | - |
? | |
UDP-glucuronic acid + bilirubin | - |
Papio anubis | UDP + bilirubin-glucuronoside | - |
? | |
UDP-glucuronic acid + bilirubin | UGT1A1 | Homo sapiens | UDP + bilirubin-glucuronoside | - |
? | |
UDP-glucuronic acid + bilirubin | - |
Papio anubis | bilirubin glucuronoside + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the UDP-glucuronosyltransferase 1A gene family | Homo sapiens |
More | the enzyme belongs to the UDP-glucuronosyltransferase 1A gene family | Papio anubis |
UDP-glucuronosyltransferase 1A | - |
Papio anubis |
UGT 1A1 | - |
Papio anubis |
UGT1A10A | - |
Papio anubis |
UGT1A10B | - |
Papio anubis |
UGT1A2A | - |
Papio anubis |
UGT1A4 | - |
Papio anubis |
UGT1A5A | - |
Papio anubis |
UGT1A5B | - |
Papio anubis |
UGT1A6 | - |
Papio anubis |
UGT1A7 | - |
Papio anubis |
UGT1A8 | - |
Papio anubis |
UGT1A9 | - |
Papio anubis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Papio anubis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Papio anubis |