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Literature summary for 2.4.1.17 extracted from
- Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation (2008), Biochem. Pharmacol., 75, 1240-1250.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hecogenin | a selective UGT1A4 inhibitor, complete inhibition of UGT1A4 at 0.05 mM | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0073 | - |
1alpha,25-dihydroxyvitamin D3 | 25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by UGT1A4 supersomes | Homo sapiens | |
| 0.0112 | - |
1alpha,25-dihydroxyvitamin D3 | 25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by liver microsomes | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P22310 | isozyme UGT1A4 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000329 | - |
25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by liver microsomes | Homo sapiens |
| 0.0000337 | - |
25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by UGT1A4 supersomes | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | substrate concentration-rate profiles of 25-O-glucuronide formation by UGT1A4, UGT2B4, and UGT2B7, overview | Homo sapiens | ? | - |
? | |
| UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3 | among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview | Homo sapiens | UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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