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Literature summary for 2.4.1.17 extracted from

  • Zhang, Y.; Yuan, J.; Fang, Z.; Tu, Y.; Hu, C.; Li, G.; Wang, L.; Deng, J.; Yao, J.; Li, H.
    Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances (2012), Molecules, 17, 4896-4903.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Inhibitors

Inhibitors Comment Organism Structure
gossypol noncompetitive inhibitin of estradiol-3-glucuronidation and propofol O-glucuronidation, competitive inhibition towards 3'-azido-3'-deoxythymidine glucuronidation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate substrate of isoform UGT2B7 Homo sapiens 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?
estradiol + UDP-alpha-D-glucuronate substrate of isoform UGT1A1 Homo sapiens UDP + estradiol 3-O-glucuronide
-
 ?
propofol + UDP-alpha-D-glucuronate substrate of isoform UGT1A9 Homo sapiens UDP + propofol D-glucuronide
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0164
-
 gossypol substrate propofol, pH 7.4, temperature not specified in the publication Homo sapiens
0.0342
-
 gossypol substrate estradiol, pH 7.4, temperature not specified in the publication Homo sapiens