Application | Comment | Organism |
---|---|---|
medicine | isoform UGT2A1 is an important detoxification enzyme in the metabolism of polycyclic aromatic hydrocarbons within target tissues for tobacco carcinogens, and functional polymorphisms in UGT2A1 may play a role in tobacco-related cancer risk | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K75R | single nucleotide polymorphism, about 25% decrease in glucuronidation activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
1-naphthol | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.044 | - |
1-naphthol | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.091 | - |
1-hydroxypyrene | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.111 | - |
1-hydroxypyrene | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.247 | - |
1-hydroxy-benzo(a)pyrene | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.261 | - |
7-hydroxy-benzo(a)pyrene | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.263 | - |
1-hydroxy-benzo(a)pyrene | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.27 | - |
5-methylchrysene-1,2-diol | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.271 | - |
3-hydroxy-benzo(a)pyrene | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.278 | - |
3-hydroxy-benzo(a)pyrene | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.284 | - |
dibenzo(a,l)pyrene-11,12-diol | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.307 | - |
dibenzo(a,l)pyrene-11,12-diol | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.308 | - |
8-hydroxy-benzo(a)pyrene | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.334 | - |
7-hydroxy-benzo(a)pyrene | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.368 | - |
8-hydroxy-benzo(a)pyrene | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.381 | - |
5-methylchrysene-1,2-diol | mutant K75R, pH 7.4, 37°C | Homo sapiens | |
0.397 | - |
benzo(a)pyrene-7,8-diol | wild-type, pH 7.4, 37°C | Homo sapiens | |
0.426 | - |
benzo(a)pyrene-7,8-diol | mutant K75R, pH 7.4, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue | Homo sapiens | - |
larynx | isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue | Homo sapiens | - |
lung | isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue | Homo sapiens | - |
additional information | no expression of isoform UGT2A1 in breast, whole brain, pancreas, prostate, kidney, liver or esophagus | Homo sapiens | - |
tonsil | isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue | Homo sapiens | - |
trachea | isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hydroxy-benzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | 1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP | - |
? | |
1-hydroxypyrene + UDP-glucuronate | - |
Homo sapiens | 1-hydroxypyrene 1-O-glucuronate + UDP | - |
? | |
1-naphthol + UDP-glucuronate | - |
Homo sapiens | 1-naphthyl 1-O-glucuronate + UDP | - |
? | |
3-hydroxy-benzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | 3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP | - |
? | |
5-methylchrysene-1,2-diol + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
7-hydroxy-benzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | 7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP | - |
? | |
8-hydroxy-benzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | 8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP | - |
? | |
benzo(a)pyrene-7,8-diol + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
additional information | isoform UGT2A1 is not active with substrates that form N-glucuronides, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, nicotine, or N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine | Homo sapiens | ? | - |
? |