Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one | i.e. atractylenolide II, one of two important efficient herbal ingredients isolated from Atractylodes macrocepha exhibits specific inhibition towards UGT2B7, with negligible influence towards other UGT isoforms | Homo sapiens | |
(8aS)-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one | i.e. atractylenolide I, one of two important efficient herbal ingredients isolated from Atractylodes macrocephala, exhibits specific competitive inhibition towards UGT2B7, with negligible influence towards other UGT isoforms | Homo sapiens | |
additional information | in silico docking and molecular homology modeling for inhibition mechanism elucidation. Atractylenolide I exerts stronger inhibition potential than atractylenolide III towards UGT2B7, which is attributed to the different hydrogen bonds and hydrophobic interactions. Inhibition kinetic analysis for the inhibition of atractylenolide I towards UGT2B7 reveals competitive inhibition by atractylenolide I | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16662 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + 4-methylumbelliferone | - |
Homo sapiens | UDP + 4-methylumbelliferyl-beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetic analysis | Homo sapiens |