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Literature summary for 2.4.1.17 extracted from

  • Tian, X.; Wang, C.; Ge, G.; Ning, J.; Ai, C.; Hong, J.; Cai, Y.; Huo, X.; Hou, J.; Liu, K.; Sun, H.; Ma, X.
    A highly selective probe for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human microsomes: Isoform specificity, kinetic characterization, and applications (2015), RSC Adv., 5, 5924-5927.
No PubMed abstract available
Search for more literature for 2.4.1.17

Application

Application Comment Organism
diagnostics 3-epideacetycinobufagin can be used specially to measure the catalytic activity of UGT2B7 in biological samples due to its exclusive substrate specificty for the compound Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3'-azido-3'-deoxythymidin slight inhibition Homo sapiens
bilirubin very low inhibition Homo sapiens
diclofenac high inhibition Homo sapiens
fluconazole high inhibition Homo sapiens
Mefenamic acid almoste complete inhibition Homo sapiens
morphine
-
 Homo sapiens
Phenylbutazone very low inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics with substrate 3-epideacetycinobufagin Homo sapiens
0.0444
-
 3-epideacetycinobufagin pH and temperature not specified in the publication Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucuronate + 3-epideacetycinobufagin Homo sapiens 3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16662
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + 3-epideacetycinobufagin
-
 Homo sapiens UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3-epideacetycinobufagin 3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview Homo sapiens UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 2B7
-
 Homo sapiens
UGT2B7
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism as an important isoform among the UGT superfamily, the enzyme UGT2B7 is involved in the glucuronidation of many clinically important drugs Homo sapiens