Cloned (Comment) | Organism |
---|---|
CSS2 quantitative expression analysis by realtime RT-PCR, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of CSS2-/- mice, phenotype, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan | Mus musculus | - |
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cartilage | - |
Mus musculus | - |
cell culture | - |
Mus musculus | - |
chondrocyte | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
additional information | CSS2 quantitative tissue expression analysis by realtime RT-PCR, overview | Mus musculus | - |
skin | - |
Mus musculus | - |
small intestine | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan | - |
Mus musculus | UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan | - |
? |
Synonyms | Comment | Organism |
---|---|---|
chondroitin sulfate synthase-2 | - |
Mus musculus |
CSS2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | CSS2 knockout mice are viable and fertile, exhibiting no overt morphological abnormalities or osteoarthritis, but their cartilage contains chondroitin sulfate chains with a shorter length and although at a similar number to wild-type. CSS2 knockout chondrocyte culture systems, together with siRNA of CSS1, reveal the presence of two CS chain species in length, suggesting two steps of CS chain polymerization; i.e., elongation from the linkage region up to Mr of about 10,00 and further extension | Mus musculus |
metabolism | CSS1 and CSS2 differently contribute to chondroitin sulfate biosynthesis, mechanism of chondroitin sulfate biosynthesis, overview. CSS1 participates in both the chondroitin sulfate chain initiation and polymerization, and CSS2 participates in the polymerization, especially in further extension | Mus musculus |
additional information | the enzyme occurs in a heterooligomer complex, chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor | Mus musculus |