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Literature summary for 2.4.1.206 extracted from

  • Marcos, N.T.; Magalhaes, A.; Ferreira, B.; Oliveira, M.J.; Carvalho, A.S.; Mendes, N.; Gilmartin, T.; Head, S.R.; Figueiredo, C.; David, L.; Santos-Silva, F.; Reis, C.A.
    Helicobacter pylori induces beta 3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x (2008), J. Clin. Invest., 118, 2325-2336.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine adhesion of Helicobacter pylori to epithelial cells is mediated by bacterial adhesins that bind carbohydrate ligands expressed by the epithelial gastric cells, bea3GnT5 transferase induction is specific to infection with highly pathogenic strains Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, overexpression of beta3GnT5 in MNK-45 cells and AGS cells, transfection with lipofectamine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with chronic Helicobacter pylori infection
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
MKN-45 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1-4)-beta-D-glucosyl-(1-1)-ceramide
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Synonyms

Synonyms Comment Organism
beta3GnT5
-
 Homo sapiens
GlcNAc transferase
-
 Homo sapiens