Literature summary for 2.4.1.208 extracted from

Vikstrom, S.; Li, L.; Wieslander, A.
The nonbilayer/bilayer lipid balance in membranes: Regulatory enzyme in Acholeplasma laidlawii is stimulated by metabolic phosphates, activator phospholipids, and double-stranded DNA (2000), J. Biol. Chem., 275, 9296-9302.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ATP	approx. 12fold stimulation at 0.75 mM, inhibition above 1.5 mM	Acholeplasma laidlawii
dsDNA	0.0007 mg/ml, 7fold activation	Acholeplasma laidlawii
fructose-1,6-bisphosphate	1 mM, approx. 18fold stimulation	Acholeplasma laidlawii
phosphate	20 mM, 5fold stimulation in the presence of 5 mM Mg2+	Acholeplasma laidlawii
phosphatidylglycerol	in vivo amounts are not enough for efficient diglucosyldiacylglycerol synthesis	Acholeplasma laidlawii
phosphatidylinositol	strong activation in the presence of 1,2-dioleoylphosphatidylglycerol	Acholeplasma laidlawii
phosphatidylinositol-4,5-bisphosphate	strong activation in the presence of 1,2-dioleoylphosphatidylglycerol	Acholeplasma laidlawii
phosphoenolpyruvate	0.5 mM, 4fold stimulation, inhibition above 1.5 mM	Acholeplasma laidlawii
sn-glycero-1-phosphate	stimulates above 15 mM	Acholeplasma laidlawii

Inhibitors

Inhibitors	Comment	Organism	Structure
2-phosphonooxyprop-2-enoate	above 1.5 mM	Acholeplasma laidlawii
ATP	above 1.5 mM, stimulation below	Acholeplasma laidlawii
sn-glycero-3-phosphate	20 mM, complete inhibition	Acholeplasma laidlawii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	maximal activity at 10 mM, inhibition above may be due to interaction with UDP-glucose	Acholeplasma laidlawii

Organism

Organism	UniProt	Comment	Textmining
Acholeplasma laidlawii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol	-	Acholeplasma laidlawii	UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D-glucopyranosyl)-sn-glycerol	-	?

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Release 2023.1 (January 2023)