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Literature summary for 2.4.1.212 extracted from

  • Itano, N.; Kimata, K.
    Mammalian hyaluronan synthases (2002), IUBMB Life, 54, 195-199.
    View publication on PubMed
Search for more literature for 2.4.1.212

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus
DNA and amino acid sequence determination and analysis, chromosome mapping of isozymes HAS1-3, genetic organization Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information site-directed mutagenesis of residues of the cytoplasmic loop of isozyme HAS1 for determining the residues required for glycosyltransferase activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis ?
-
 ?
additional information Mus musculus regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis, isozymes exhibit different functions in tumor growth, progression, and determination of malignancy ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-
Mus musculus
-
 3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-

Purification (Commentary)

Purification (Comment) Organism
recombinant isozymes by immunoaffinity chromatography Mus musculus
recombinant isozymes by immunoaffinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis Homo sapiens ?
-
 ?
additional information regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis, isozymes exhibit different functions in tumor growth, progression, and determination of malignancy Mus musculus ?
-
 ?
additional information the isozymes form products of different size, HA synthesis modeling, active site and substrate binding site are located on the big cytoplasmic loop Mus musculus ?
-
 ?
additional information the isozymes form products of different size, HA synthesis modeling, active site and substrate binding site are located on the big cytoplasmic loop Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More determination of isozyme structures with 7 putative transmembrane regions, 2 thereof at the N-terminus and 5 at the C-terminus, and a big cytoplasmic loop harboring the active site and the substrate binding site Mus musculus
More determination of isozyme structures with 7 putative transmembrane regions, thereof 2 at the N-terminus and 5 at the C-terminus, and a big cytoplasmic loop harboring the active site and the substrate binding site Homo sapiens

Synonyms

Synonyms Comment Organism
HA synthase
-
 Mus musculus
HA synthase
-
 Homo sapiens
HAS
-
 Mus musculus
HAS
-
 Homo sapiens