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Literature summary for 2.4.1.212 extracted from

  • Ghosh, A.; Kuppusamy, H.; Pilarski, L.M.
    Aberrant splice variants of HAS1 (hyaluronan synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer (2009), J. Biol. Chem., 284, 18840-18850.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine HAS1 variant Vc is transforming in vitro and tumorigenic in vivo when introduced as a single oncogene to untransformed cells. In co-transfected cells, full length HAS1 and HAS1 variants interact with themselves and with each other to form heteromeric multiprotein assemblies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92839 isoform HAS1
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Subunits

Subunits Comment Organism
More in co-transfected cells, full length HAS1 and HAS1 splice variants interact with themselves and with each other to form heteromeric multiprotein assemblies Homo sapiens

Synonyms

Synonyms Comment Organism
hyaluronan synthase 1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens comparison of full-length HAS1 isoform and its splice variants Va, Vb, and Vc. When co-expressed, the properties of HAS1 variants are dominant over those of full length HAS1. Full length HAS1 appears to be diffusely expressed in the cell, but HAS1 variants are concentrated in the cytoplasm and/or Golgi apparatus. HAS1 variants synthesize detectable de novo hyaluronan intracellularly. Each of the HAS1 variants is able to relocalize full length HAS1 protein from diffuse cytoskeleton-anchored locations to deeper cytoplasmic spaces. The HAS1-variants-mediated relocalization occurs through strong molecular interactions, which also serve to protect full length HAS1 from its otherwise high turnover kinetics additional information