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Literature summary for 2.4.1.212 extracted from

  • Medina, A.P.; Lin, J.; Weigel, P.H.
    Hyaluronan synthase mediates dye translocation across liposomal membranes (2012), BMC Biochem., 13, 2-2.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.212

Protein Variants

Protein Variants Comment Organism
K48E site-directed mutagenesis, alteration of K48 within membrane domain 2 causes decreased activity and HA product size Streptococcus dysgalactiae subsp. equisimilis
K48F site-directed mutagenesis, alteration of K48 within membrane domain 2 causes decreased activity and HA product size Streptococcus dysgalactiae subsp. equisimilis
additional information addition of purified HAS to liposomes preloaded with the fluorophore Cascade Blue, CB, which is translocated through the membrane and secreted by HAS, overview. SeHAS-mediated CB efflux is greater from liposomes made with an activating lipid, tetraoleoyl cardiolipin, compared to an inactivating lipid, tetramyristoyl cardiolipin Streptococcus dysgalactiae subsp. equisimilis

Inhibitors

Inhibitors Comment Organism Structure
additional information heating, oxidization or cysteine modification with N-ethylmaleimide inhibit the enzyme Streptococcus dysgalactiae subsp. equisimilis
N-ethylmaleimide
-
 Streptococcus dysgalactiae subsp. equisimilis

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Streptococcus dysgalactiae subsp. equisimilis 5886
-

Organism

Organism UniProt Comment Textmining
Streptococcus dysgalactiae subsp. equisimilis
-
-
-

Subunits

Subunits Comment Organism
monomer
-
 Streptococcus dysgalactiae subsp. equisimilis

Synonyms

Synonyms Comment Organism
HAS
-
 Streptococcus dysgalactiae subsp. equisimilis

General Information

General Information Comment Organism
physiological function hyaluronan synthase mediates dye translocation across liposomal membranes Streptococcus dysgalactiae subsp. equisimilis