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Literature summary for 2.4.1.212 extracted from

  • Nykopp, T.K.; Rilla, K.; Tammi, M.I.; Tammi, R.H.; Sironen, R.; Haemaelaeinen, K.; Kosma, V.M.; Heinonen, S.; Anttila, M.
    Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma (2010), BMC Cancer, 10, 512.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genes HAS1, HAS2 and HAS3, quantitative expression analysis in benign and malign endometrial tissue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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isozymes HAS1, HAS2 and HAS3
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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Homo sapiens
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additional information while immunoreactivity for HASs increases in the cancer cells, tumor mRNA levels for HASs are not changed, suggesting that reduced turnover of HAS protein may also have contributed to the accumulation of hyaluronan, quantitative expression analysis, overview Homo sapiens
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uterine endometrial carcinoma cell 35 endometrial tissue biopsies from 35 patients, including proliferative and secretory endometrium, post-menopausal proliferative endometrium, complex atypical hyperplasia, grade 1 and grade 2 + 3 endometrioid adenocarcinomas. Immunoreactivity of all HAS proteins is increased in the cancer epithelium Homo sapiens
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uterine endometrium
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Homo sapiens
-