Literature summary for 2.4.1.212 extracted from

Karousou, E.; Kamiryo, M.; Skandalis, S.S.; Ruusala, A.; Asteriou, T.; Passi, A.; Yamashita, H.; Hellman, U.; Heldin, C.H.; Heldin, P.
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination (2010), J. Biol. Chem., 285, 23647-23654.

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Cloned(Commentary)

Cloned (Comment)	Organism
ectopic expression of Flag- and 6myc-HAS2 in COS-1 cells as homodimers, co-expression with Flag-HAS3 leads to formation of heterodimers	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
K190R	site-directed mutagenesis, inactive mutant, K190R-mutated HAS2 forms dimers with wild-type HAS2 and quenches the activity of wild-type HAS2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isozymes HAS2 and HAS3	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	HAS2 is ubiquitinated on Lys190, HAS2 is both mono- and polyubiquitinated	Mus musculus

Synonyms

Synonyms	Comment	Organism
Has2	-	Mus musculus
Has3	-	Mus musculus
hyaluronan synthase 2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	catalytically inactive mutant K190R HAS2 forms dimers with wild-type HAS2 and quenches the activity of wild-type HAS2	Mus musculus

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Release 2023.1 (January 2023)