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Literature summary for 2.4.1.212 extracted from

  • Toerroenen, K.; Nikunen, K.; Kaernae, R.; Tammi, M.; Tammi, R.; Rilla, K.
    Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes (2014), Histochem. Cell Biol., 141, 17-31.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of EGFP-tagged isozyme HAS1 in MCF-7 cells and localization to the Golgi apparatus Mus musculus
recombinant expression of EGFP-tagged isozyme HAS2 in MCF-7 cells and localization to the endoplasmic reticulum Mus musculus
recombinant expression of EGFP-tagged isozyme HAS3 in MCF-7 cells and localization to the Golgi apparatus Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
endoplasmic reticulum isozyme HAS2 has the brightest signal in the endoplasmic reticulum Mus musculus 5783
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Golgi apparatus isozyme HAS1 has the brightest signal in the Golgi network Mus musculus 5794
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Golgi apparatus isozyme HAS3 has the brightest signal in the Golgi and microvil­lous protrusions Mus musculus 5794
-
plasma membrane in natural membrane extensions Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus O08650
-
-
Mus musculus P70312
-
-
Mus musculus Q61647
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Mus musculus
-
embryo expression of different HAS isoenzymes during embryonic development, overview. Intense hyaluronan staining is observed throughout the development in the tissues of mesodermal origin, like heart and cartilages, but also for example during the maturation of kidneys and stratified epithelia. In general, staining for one or several HAS isozymes correlates with hyaluronan staining. While epithelial cells are mostly nega­tive for HASs, stratified epithelia become HAS positive during differentiation Mus musculus
-
embryo expression of different HAS isoenzymes during embryonic development, overview. Intense hyaluronan staining is observed throughout the development in the tissues of mesodermal origin, like heart and cartilages, but also for example during the maturation of kidneys and stratified epithelia. In general, staining for one or several HAS isozymes correlates with hyalu­ronan staining. While epithelial cells are mostly nega­tive for HASs, stratified epithelia become HAS positive during differentiation Mus musculus
-
epithelium
-
Mus musculus
-
fibroblast skin fibroblast Mus musculus
-
HaCaT cell
-
Mus musculus
-
heart
-
Mus musculus
-
keratinocyte
-
Mus musculus
-
kidney
-
Mus musculus
-
skin
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
HAS1
-
Mus musculus
Has2
-
Mus musculus
Has3
-
Mus musculus

General Information

General Information Comment Organism
evolution the three HAS isoenzymes, HAS1, HAS2, and HAS3, expressed in mammalian cells differ in their enzymatic properties and regulation by external stimuli Mus musculus
physiological function hyaluronan is the largest and one of the most abundant glycosaminoglycans of the extracellular space. Hyaluronan syn­thases are glycosyltransferases acting on the inner face of plasma membrane, adding alternately glucuronic acid and N-acetylglucosamine to the reducing end of the growing chain. Hyaluronan synthase forms a reserve that is transported to the plasma membrane for rapid activation of hyaluronan synthesis. The levels and localizations of HAS isoforms are likely to be highly important in processes like embryonic develop­ment, wound healing, inflammation, and malignant growth Mus musculus