Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | OFUT1 associates with Notch at the cell surface and promotes the constitutive endocytosis of Notch receptors | Drosophila sp. (in: flies) | 9986 | - |
endoplasmic reticulum | OFUT1 is required for the correct folding of Notch receptors in the endoplasmic reticulum and their subsequent trafficking to the cell surface | Drosophila sp. (in: flies) | 5783 | - |
additional information | adherens junction | Drosophila sp. (in: flies) | - |
- |
plasma membrane | OFUT1 promotes transcytosis of Notch from the apical plasma membrane to the adherens junctions | Drosophila sp. (in: flies) | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila sp. (in: flies) | - |
- |
- |
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
O-fucosyltransferase 1 | - |
Drosophila sp. (in: flies) |
O-fucosyltransferase 1 | - |
Mus musculus |
OFUT1 | - |
Drosophila sp. (in: flies) |
Pofut1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of OFUT1 results in the phenotype that is characteristic of Notch loss of function. Loss of OFUT1 leads to the loss of cell surface expression and the intracellular accumulation of Notch receptors. Secretion of Notch is impaired in OFUT1-depleted S2 cells and the abnormal endoplasmic reticulum accumulation of Notch receptors is observed in Ofut1 mutant clones in Drosophila wing imaginal discs | Drosophila sp. (in: flies) |
malfunction | loss of Pofut1 results in the phenotype that is characteristic of Notch loss of function | Mus musculus |
physiological function | is essential for Notch signalling | Mus musculus |
physiological function | is essential for Notch signalling. Ability of OFUT1 to promote Notch secretion does not depend on its enzyme activity, suggesting the chaperon-like role of OFUT1 | Drosophila sp. (in: flies) |