Literature summary for 2.4.1.221 extracted from

Yao, D.; Huang, Y.; Huang, X.; Wang, W.; Yan, Q.; Wei, L.; Xin, W.; Gerson, S.; Stanley, P.; Lowe, J.B.; Zhou, L.
Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions (2011), Blood, 117, 5652-5662.

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Protein Variants

Protein Variants	Comment	Organism
additional information	generation of Pofut1+/-/FX-/- mutant mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	floxed Pofut1 (Pofut1F/F) mice and Pofut1 heterozygous mice (Pofut1+/-)	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Pofut1	-	Mus musculus
protein O-fucosyltransferase 1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mice lacking Pofut1 show myeloid hyperplasia and impaired lymphopoiesis. Mx-Cre/Pofut1F/F mice splenomegaly show in the bone marrow a decrease in T and B lymphocytes and an expansion of mature granulocytes and myeloid progenitors, mutant mice phenotypes, detailed overview. Mx-Cre/Pofut1F/F marrow progenitors have defective T lymphopoiesis and enhanced myeloid development in vitro that is correlated with decreased Notch ligand binding.. Defective T-cell development and myeloid hyperplasia are rescued by reinstating Notch1 signaling. Heterozygosity of Pofut1 affects rescue of FX-/- mice myeloid hyperplasia by exogenous fucose	Mus musculus

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Release 2023.1 (January 2023)