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Literature summary for 2.4.1.221 extracted from

  • Ishikawa, H.; Ayukawa, T.; Nakayama, M.; Higashi, S.; Kamiyama, S.; Nishihara, S.; Aoki, K.; Ishida, N.; Sanai, Y.; Matsuno, K.
    Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of notch in Drosophila (2010), J. Biol. Chem., 285, 4122-4129.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum lumen
-
Drosophila melanogaster 5788
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Golgi apparatus
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Drosophila melanogaster 5794
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Synonyms

Synonyms Comment Organism
O-fucosyltransferase 1
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Drosophila melanogaster

General Information

General Information Comment Organism
physiological function Notch is a transmembrane receptor that shares homology with proteins containing epidermal growth factor-like repeats and mediates the cell-cell interactions necessary for many cell fate decisions. O-fucosyltransferase 1 catalyzes the O-fucosylation of these epidermal growth factor-like repeats. This O-fucose elongates, resulting in an O-linked tetrasaccharide that regulates the signaling activities of Notch. Fucosylation occurs in the lumen of the endoplasmicreticulum and Golgi. GDP-fucose uptake into the ER and Golgi is essential for fucosylation, Efr, a multifunctional nucleotide sugar transporter, and Golgi GDP-fucose transporter Gfr are involved in the biosynthesis of heparan sulfate-glycosaminoglycan chains and the O-fucosylation of Notch. Gfr but not Efr is crucial for the fucosylation of N-glycans, overview Drosophila melanogaster