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Literature summary for 2.4.1.222 extracted from

  • Shao, L.; Moloney, D.J.; Haltiwanger, R.
    Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region (2003), J. Biol. Chem., 278, 7775-7782.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch + UDP-D-GlcNAc Drosophila melanogaster enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors beta-D-glucosaminyl-Notch + UDP
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Reaction

Reaction Comment Organism Reaction ID
UDP-beta-D-GlcNAc + PCQNGGS(O-beta-L-fucosyl)-CKDQL = UDP + PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL mechanism Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor VII EGF repeat + UDP-D-GlcNAc Manic fringe modifies O-fucose on mouse Notch1 at extracellular epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region expressed in Lec1 cells Drosophila melanogaster beta-D-glucosaminyl-factor VII EGF repeat + UDP
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additional information activity on different factor VII EGF repeat containing protein fragments, overview Drosophila melanogaster ?
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Notch + UDP-D-GlcNAc enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
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?
Notch1 + UDP-D-GlcNAc Manic fringe modifies O-fucose on mouse Notch1 at extracellular epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region expressed in Lec1 cells Drosophila melanogaster beta-D-glucosaminyl-Notch1 + UDP
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?

Synonyms

Synonyms Comment Organism
beta1,3-N-acetylglusoaminyltransferase
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Drosophila melanogaster
Fringe protein
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Drosophila melanogaster
Manic fringe
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Drosophila melanogaster