Cloned (Comment) | Organism |
---|---|
expression of Radical Fringe, Lunatic Fringe, and Manic Fringe in HEK 293T cells and NIH 3T3 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of Radical Fringe, Lunatic Fringe, and Manic Fringe in 293T cells and NIH 3T3 cells leads to increased receptor Delta1 binding and activation of Notch1 signaling, and to suppression of Jagged1-induced signaling by Lunatic and Manic Fringe, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1 | ? | - |
? | |
Notch + UDP-D-GlcNAc | Rattus norvegicus | different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1 | beta-D-glucosaminyl-Notch + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
different enzyme forms, i.e. Radical Fringe, Lunatic Fringe, and Manic Fringe | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1 | Rattus norvegicus | ? | - |
? | |
Notch + UDP-D-GlcNAc | - |
Rattus norvegicus | beta-D-glucosaminyl-Notch + UDP | - |
? | |
Notch + UDP-D-GlcNAc | different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1 | Rattus norvegicus | beta-D-glucosaminyl-Notch + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FNG | - |
Rattus norvegicus |
fringe glycosyltransferase | - |
Rattus norvegicus |
Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase | - |
Rattus norvegicus |