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Literature summary for 2.4.1.222 extracted from

  • Yang, L.T.; Nichols, J.T.; Yao, C.; Manilay, J.O.; Robey, E.A.; Weinmaster, G.
    Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1 (2005), Mol. Biol. Cell, 16, 927-942.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of Radical Fringe, Lunatic Fringe, and Manic Fringe in HEK 293T cells and NIH 3T3 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression of Radical Fringe, Lunatic Fringe, and Manic Fringe in 293T cells and NIH 3T3 cells leads to increased receptor Delta1 binding and activation of Notch1 signaling, and to suppression of Jagged1-induced signaling by Lunatic and Manic Fringe, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1 ?
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?
Notch + UDP-D-GlcNAc Rattus norvegicus different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1 beta-D-glucosaminyl-Notch + UDP
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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different enzyme forms, i.e. Radical Fringe, Lunatic Fringe, and Manic Fringe
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1 Rattus norvegicus ?
-
?
Notch + UDP-D-GlcNAc
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Rattus norvegicus beta-D-glucosaminyl-Notch + UDP
-
?
Notch + UDP-D-GlcNAc different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1 Rattus norvegicus beta-D-glucosaminyl-Notch + UDP
-
?

Synonyms

Synonyms Comment Organism
FNG
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Rattus norvegicus
fringe glycosyltransferase
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Rattus norvegicus
Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase
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Rattus norvegicus