Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme modifies EGF repeats in the Notch extracellular domain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00587 | gene MFNG | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | manic fringe is highly expressed in claudin-low breast cancer | Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme modifies EGF repeats in the Notch extracellular domain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Manic fringe | - |
Homo sapiens |
MFng | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Mfng silencing in claudin-low breast cancer CLBC cell lines reduces cell migration, tumorsphere formation, and in vivo tumorigenicity associated with a decrease in the stem-like cell population. Lfng deficiency induces basal-like breast cancer | Homo sapiens |
physiological function | manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated phosphoinositide kinase PIK3CG induction. The enzyme functions as an oncogen in claudin-low breast cancer. Phosphoinossitide kinase Pik3cg is a direct target of enzyme Mfng-enhanced Notch signaling in claudin-low breast cancer | Homo sapiens |