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Literature summary for 2.4.1.225 extracted from

  • McCormick, C.; Duncan, G.; Goutsos, K.T.; Tufaro, F.
    The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heapran sulfate (2000), Proc. Natl. Acad. Sci. USA, 97, 668-673.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.225

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum transmembrane glycoprotein Homo sapiens 5783
-
endoplasmic reticulum transmembrane glycoprotein Bos taurus 5783
-
Golgi apparatus transmembrane glycoprotein Homo sapiens 5794
-
Golgi apparatus transmembrane glycoprotein Bos taurus 5794
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 enzyme EXT2, enzyme EXT1 from Homo sapiens
-
Homo sapiens
-
 enzyme EXT1, EXT2 constructs from Bos taurus
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
glycoprotein
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell enzyme EXT1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information formation of homo- and heterooligomeric complexes of EXT1 and EXT2, heterooligomeric complexes have substantially higher glycosyltransferase activity than EXT1 or EXT2 alone Bos taurus ?
-
 ?
additional information formation of homo- and heterooligomeric complexes of EXT1 and EXT2, heterooligomeric complexes have substantially higher glycosyltransferase activity than EXT1 or EXT2 has alone Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + alpha-D-glucuronosyl-(1-4)-N-acetylglucoside
-
 Homo sapiens UDP + alpha-N-acetyl-D-glucosaminyl-alpha-D-glucuronosyl-(1-4)-N-acetylglucoside
-
 ?
UDP-N-acetyl-D-glucosamine + alpha-D-glucuronosyl-(1-4)-N-acetylglucoside
-
 Bos taurus UDP + alpha-N-acetyl-D-glucosaminyl-alpha-D-glucuronosyl-(1-4)-N-acetylglucoside
-
 ?

Subunits

Subunits Comment Organism
More formation of homo- and heterooligomeric complexes of EXT1 and EXT2, heterooligomeric complexes have substantially higher glycosyltransferase activity than EXT1 or EXT2 alone Bos taurus
More formation of homo- and heterooligomeric complexes of EXT1 and EXT2, heterooligomeric complexes have substantially higher glycosyltransferase activity than EXT1 or EXT2 has alone Homo sapiens