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Literature summary for 2.4.1.227 extracted from

  • Egan, A.J.; Biboy, J.; vant Veer, I.; Breukink, E.; Vollmer, W.
    Activities and regulation of peptidoglycan synthases (2015), Philos. Trans. R. Soc. Lond. B Biol. Sci., 370, 20150031.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.227

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-
membrane
-
 Micrococcus flavus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol Escherichia coli lipid I UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid II ?
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol Micrococcus flavus lipid I UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid II ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene murG
-
Micrococcus flavus
-
 gene murG
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UDP-GlcNAc is incorporated into lipid II using GlcNAc. MurG is also able to exchange the GlcNAc of the lipid II head group with GlcNAc of UDPGlcNAc, a simple exchange reaction Escherichia coli ?
-
 ?
additional information UDP-GlcNAc is incorporated into lipid II using GlcNAc. MurG is also able to exchange the GlcNAc of the lipid II head group with GlcNAc of UDPGlcNAc, a simple exchange reaction Micrococcus flavus ?
-
 ?
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid I Escherichia coli UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid II ?
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid I Micrococcus flavus UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol lipid II ?

Synonyms

Synonyms Comment Organism
MurG
-
 Escherichia coli
MurG
-
 Micrococcus flavus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Micrococcus flavus

General Information

General Information Comment Organism
physiological function the biochemical production of lipid II requires four components, the lipid carrier undecaprenyl phosphate, UDP-MurNAc-pentapeptide, UDP-GlcNAc and the enzymes catalysing the formation of lipid II from these substrates, MraY and MurG Escherichia coli
physiological function the biochemical production of lipid II requires four components, the lipid carrier undecaprenyl phosphate, UDP-MurNAc-pentapeptide, UDP-GlcNAc and the enzymes catalysing the formation of lipid II from these substrates, MraY and MurG Micrococcus flavus