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Literature summary for 2.4.1.228 extracted from

  • Kojima, Y.; Fukumoto, S.; Furukawa, K.; Okajima, T.; Wiels, J.; Yokoyama, K.; Suzuki, Y.; Urano, T.; Ohta, M.; Furukawa, K.
    Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of Globo series glycosphingolipids (2000), J. Biol. Chem., 275, 15152-15156.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in mouse fibroblast L cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0545
-
 lactosylceramide
-
 Homo sapiens
0.132
-
 UDP-galactose
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosylceramide Homo sapiens
-
 UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosylceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 melanoma cell line SK-MEL-37
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000001
-
 lactosylceramide as acceptor Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosylceramide
-
 Homo sapiens UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosylceramide
-
 ?
UDP-galactose + galactosylceramide
-
 Homo sapiens ?
-
 ?
UDP-galactose + lactosylceramide
-
 Homo sapiens UDP + globotriaosylceramide
-
 ?