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Literature summary for 2.4.1.255 extracted from

  • Lazarus, B.D.; Love, D.C.; Hanover, J.A.
    Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates (2006), Glycobiology, 16, 415-421.
    View publication on PubMed
Search for more literature for 2.4.1.255

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000025
-
 Nup62
-
 Homo sapiens
0.000227
-
 Nup62
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
nucleocytoplasm
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
 sOGT Homo sapiens
103000
-
 mOGT Homo sapiens
116000
-
 ncOGT Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens catalyzes the transfer of O-linked GlcNAc to serine or threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyzes the transfer of O-linked GlcNAc to serine or threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders Homo sapiens ?
-
 ?
UDP-GlcNAc + Nup62 protein
-
 Homo sapiens UDP + N-acetyl-D-glucosmainyl-[Nup62 protein]
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [Nup62 protein]-L-serine
-
 Homo sapiens UDP + [Nup62 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
-
 ?

Synonyms

Synonyms Comment Organism
mOGT isoform Homo sapiens
More the short isoform of OGT (sOGT) does not glycosylate any of the substrates tested, although it retains a potentially active catalytic domain Homo sapiens
ncOGT isoform Homo sapiens
O-GlcNAc transferase
-
 Homo sapiens
O-linked N-acetylglucosaminyltransferase
-
 Homo sapiens
OGT
-
 Homo sapiens
sOGT isoform Homo sapiens