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Literature summary for 2.4.1.255 extracted from

  • Liu, Y.; Li, X.; Yu, Y.; Shi, J.; Liang, Z.; Run, X.; Li, Y.; Dai, C.L.; Grundke-Iqbal, I.; Iqbal, K.; Liu, F.; Gong, C.X.
    Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain (2012), PLoS ONE, 7, e43724.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.255

Inhibitors

Inhibitors Comment Organism Structure
alloxan
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
nucleoplasm
-
 Rattus norvegicus 5654
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 x * 70000, shortest isoform sOGT, SDS-PAGE Rattus norvegicus
103000
-
 x * 103000, mitochondrial isoform mOGT, SDS-PAGE Rattus norvegicus
116000
-
 x * 116000, nucleocytoplasmic isoform ncOGT, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P56558
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc + p62 protein
-
 Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-[p62 protein]
-
 ?

Subunits

Subunits Comment Organism
? x * 103000, mitochondrial isoform mOGT, SDS-PAGE Rattus norvegicus
? x * 116000, nucleocytoplasmic isoform ncOGT, SDS-PAGE Rattus norvegicus
? x * 70000, shortest isoform sOGT, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
 Rattus norvegicus
O-linked N-acetylglucosamine transferase
-
 Rattus norvegicus
OGT
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus isoform ncOGT level decreases gradually after 1 month and reduces by up to 60% when rats are 2 years old. The brain sOGT level is nearly undetectable during early development and increases markedly after 15 days after birth, although its level decreases again at age of 2 years down